A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin
González Ordóñez, A.J.; Medina Rodriguez, J.M.; Fernández Alvarez, C.R.; Macias Robles, M.D.; Coto García, E.
Haematologica 83(11): 1050-1051
1998
ISSN/ISBN: 0390-6078 PMID: 9864932 Document Number: 494456
It is well established that genetic disorders interact with environmental factors to cause thrombotic diseases. Therefore, antithrombin, protein C, protein S deficiencies and the more recently described factor V Leiden and prothrombin mutations are currently been investigated to explain some thrombophilic states. We report the case of a 63-year-old man who developed two transient ischemic attacks and two years later an extensive femoro-iliac venous thrombosis. He was genotyped as FV R506Q negative and FII G20210A positive in homozygous state (FII 20210AA).