Severe trauma leads to damaged signal transduction with inhibited secretion of cytokines
Oberholzer, A.; Steckholzer, U.; Trentz, O.; Ertel, W.
Langenbecks Archiv für Chirurgie. Suppl. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 115(Suppl I): 39-41
1998
ISSN/ISBN: 0942-2854 PMID: 14518208 Document Number: 494269
The reduced secretion if IL-1 beta after severe injury seems to be due to disturbances in signal transduction pathways. Protein-tyrosine kinases are necessary for endotoxin-induced secretion of IL-1 beta, while protein kinase C antagonizes this effect.