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Characterization of spontaneous transplant tolerance exemplified by orthotopic liver transplantation: significance of Fas ligand induced programmed cell death

Fändrich, F.; Lin, X.; Klöppel, G.; Kremer, B.

Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 115(Suppl I): 361-365

1998

ISSN/ISBN: 0942-2854
PMID: 14518276
Document Number: 493985
For the first time, this study provides strong evidence that hepatocytes express functional Fas-ligand protein after orthotopic liver transplantation in specific allogeneic strain combinations. Fas-L expression correlates with intra-graft elimination of alloreactive T cells and subsequent tolerance induction. Thus, detection of Fas-L offers the possibility to be used as a marker protein for tolerized liver transplants.

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