Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria
Perazella, M.A.; Kashgarian, M.; Cooney, E.
Clinical Nephrology 50(3): 194-196
1998
ISSN/ISBN: 0301-0430 PMID: 9776425 Document Number: 493646
Indinavir has been described to cause crystalluria and nephrolithiasis in a variable number of treated patients. Acute renal failure, often reversible with discontinuation of the medication, induction of a diuresis and correction of urinary obstruction if present, occurs in a smaller percent of patients. One recent report described renal biopsy findings, indinavir crystals within cellular casts in the collecting tubules, in a patient receiving this antiretroviral agent. We report a second case of a patient with mild renal insufficiency and pyuria following indinavir therapy and describe similar renal biopsy findings.