Glutamate receptor activation: a four-step program
Miller, C.
Science 280(5369): 1547-1548
1998
ISSN/ISBN: 0036-8075 PMID: 9644020 Document Number: 493609
In this issue, C. Rosenmund and colleagues propose that the ionotropic glutamate receptor channels in the postsynaptic membrane of vertebrate nerve cells are tetramers of independent subunits. Many other neurotransmitter-activated ion channels are known to be composed of five identical or similar subunits surrounding a central transmembrane pore. The researchers concede that their conclusion is based on a very simplistic representation of ligand binding.
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