Suppression of growth and transformation and induction of apoptosis by EGR-1
Liu, C.; Rangnekar, V.M.; Adamson, E.; Mercola, D.
Cancer Gene Therapy 5(1): 3-28
1998
ISSN/ISBN: 0929-1903 PMID: 9476963 Document Number: 493419
Although cloned as an "immediate-early gene,' recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (TGF-beta1) gene and cooperation with Sp1, Jun-B, p21WAF1/Cip1, and stimulates apoptosis by transactivation of the p53 gene.
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