Time-dependent hemodynamic effects of monosan (Isosorbide-5-mononitrate) in anginal patients
Zholdin, B.K.; Zaslavskaia, R.M.; Zhamankulov, K.A.
Klinicheskaia Meditsina 76(4): 30-32
1998
ISSN/ISBN: 0023-2149 PMID: 9613078 Document Number: 492870
Chronosensitivity to monosan was studied in acute clinicopharmacological tests at 7.00, 11.00, 15.00, 19.00 and 23.00 in 20 patients with ischemic heart disease, angina pectoris (class II-III). Arterial pressure, heart rate, hemodynamic parameters were measured before monosan intake, 1.5, 2, 3 and 21 hours after the intake of 20 mg. The findings indicate the existence of chronosensitivity of hemodynamics to monosan, circadian rhythm of sensitivity of the heart rate, systolic pressure, peripheral resistance. Acrophase of the sensitivity rhythm of the heart rate occurred at 13.42, systolic pressure at 21.54, mean arterial pressure at 00.41, total and peripheral resistance at 14.13, 15.18, respectively.