Identification and characterization of multiple HLA-A24-restricted HIV-1 CTL epitopes: strong epitopes are derived from V regions of HIV-1
Ikeda-Moore, Y.; Tomiyama, H.; Miwa, K.; Oka, S.; Iwamoto, A.; Kaneko, Y.; Takiguchi, M.
Journal of Immunology 159(12): 6242-6252
1998
ISSN/ISBN: 0022-1767 PMID: 9550428 Document Number: 492537
These authors previously identified multiple HIV-1 cytotoxic T lymphocyte (CTL) epitopes presented by HLA-B*3501 molecules using reverse immunogenetics, which is a strategy to identify CTL epitopes from a panel of peptides matched to an HLA class I-binding peptide motif. In the present study, this strategy was used to identify HIV-1 CTL epitopes presented by HLA-A*2402, which is the most popular HLA class I allele in Japan and a common allele worldwide. The epitopes were confirmed by generating the specific CTL clones and were further characterized. The analysis of HLA-A24-restricted HIV-1 CTLs in HIV-1-infected individuals carrying HLA-A24 showed that they have strong HLA-A24-restricted CTLs for multiple epitopes derived from the diverse region of HIV-1.