Castleman's disease and chromophobe carcinoma of the kidney. An incidental association?

Tissier, F.; de Pinieux, G.; Thiounn, N.; Merran, S.; Gessain, A.; Tulliez, M.; Vieillefond, A.

Annales de Pathologie 18(5): 429-431

1998


ISSN/ISBN: 0242-6498
PMID: 9864581
Document Number: 492008
We report a case of Castleman's disease in a 65-year-old female, revealed by a renal tumor associated with inter-aortico-cava adenopathies and renal chromophobe cell carcinoma. This observation points to the difficulties in differentiating local Castleman's disease, which may be cured by surgical excision, from multicentric disease associated with a dysimmune syndrome of uncertain prognosis. The association of multicentric Castleman's disease with a carcinoma has rarely been described. It could be the emergence of a neoplasia in a context of dysimmunity or Castleman's disease might be related to the production of interleukin 6 by a renal carcinoma.

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