A comparison of the pharmacology of salbutamol with that of isoprenaline, orciprenaline and trimetoquinol
Brittain, R.T.
Postgraduate Medical Journal 47(Suppl): 11-16
1971
ISSN/ISBN: 0032-5473 PMID: 5572509 Document Number: 4918
lsoprenaline does not differentiate between preceptors in different tissues and the selectivity of action of orciprenaline for ß-receptors in bronchial muscle is small. The pharmacological properties of trimetoquinol are interesting: it acts as a potent partial agonist in relaxing bronchial smooth muscle and has no effect on cardiac muscle of the guinea-pig. However, in other species, rat, cat and dog, trimetoquinol causes positive chronotropic and inotropic effects. It is too early to assess the clinical results obtained with this ß-stimulant. Salbutamol differentiates between ß-receptors in different tissues and, unlike isoprenaline, this ß-stimulant has a prolonged duration of action. This result was expected since salbutamol is not a substrate for catechol-O-methyl transferase or sulphatase enzymes. All the animal results suggested that salbutamol would be an improved bronchodilator in man, being more selective, longer acting and safer than isoprenaline and more effective and less likely to cause side-effects than orciprenaline. The pharmacological forecasts for salbutamol were well founded in the light of subsequent results obtained in the human studies and clinical trials with this ß-adrenoceptor stimulant.
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