Analgesic agents: comparative evaluation, mechanisms of action, prospects
Churiukanov, V.V.
Anesteziologiia i Reanimatologiia 5: 4-11
1998
ISSN/ISBN: 0201-7563 PMID: 9866237 Document Number: 491042
A classification of analgesics based on the localization and mechanisms of their action is proposed. Opioid analgesics are compared: opioid receptor agonists, agonists-antagonists, and partial agonists. Central-action nonopioid analgesics are listed: alpha 2-adrenomimetics, Na- and K-channel blockers, reverse monoamine neuronal capture inhibitors, stimulating amino acid antagonists, etc. Peripheral-action analgesics (cycloxygenase inhibitors) are described.