Characterisation of a novel AGE-compound derived from lysine and 3-deoxyglucosone
Skovsted, I.C.; Christensen, M.; Breinholt, J.; Mortensen, S.B.
Cellular and Molecular Biology 44(7): 1159-1163
1998
ISSN/ISBN: 0145-5680 PMID: 9846898 Document Number: 490954
Dicarbonyl compounds are supposed to be reactive intermediates in the non-enzymatic glycation of proteins. A process that eventually could lead to the development of late diabetic complications. Glyoxal lysine dimer (GOLD) and methylglyoxal lysine dimer (MOLD) have previously been described as such reactive dicarbonyls. Here a new compound 3-deoxyglucosone lysine dimer (DOLD), a cross-link resulting from the reaction between hippuryl-lysine and 3-deoxyglucosone, has been isolated by HPLC and the structure determined by mass spectrometry and NMR.