Top Abstract Purchase Related
Home
>
Node
>
Subnode

Role of iron and copper during benzene toxicity

Ahmad, S.; Murthy, R.C.; Rao, G.S.

Indian Journal of Experimental Biology 36(3): 283-286

1998

ISSN/ISBN: 0019-5189
PMID: 9754061
Document Number: 490331
Role of transition metal ions in expression of benzene toxicity has been suggested. Intraperitoneal administration of benzene to female albino rats daily for 10 days resulted in accumulation of iron in liver nuclei, without any change in copper content. Incubation of hydroquinone (HQ), one of the principal metabolites of benzene with rat liver nuclei resulted in formation of thiobarbituric acid reactive products (TBAR). However, presence of bathocuproine, a copper chelator and EDTA, an iron chelator caused significant inhibition of TBAR release. Thus, the present study revealed that iron accumulation and involvement of copper in nuclear damage induced by HQ.

Document emailed within 1 workday
Secure & encrypted payments

Gipp, W.F.; Pond, W.G.; Kallfelz, F.A.; Tasker, J.B.; Van Campen, D.R.; Krook, L.; Visek, W.J. 1974: Effect of dietary copper, iron and ascorbic acid levels on hematology, blood and tissue copper, iron and zinc concentrations and 64Cu and 59Fe metabolism in young pigs Journal of Nutrition 104(5): 532-541
Abdel-Mageed, A.B.; Oehme, F.W. 1990: A review of the biochemical roles, toxicity and interactions of zinc, copper and iron: I. Zinc Veterinary and Human Toxicology 32(1): 34-39
Avakian, Z.A.; Rabotnova, I.L. 1971: Comparative toxicity of free ions of copper and copper complexes with organic acids for Candida utilis Mikrobiologiia 40(2): 305-310
Owen, C.A. 1973: Effects of iron on copper metabolism and copper on iron metabolism in rats American Journal of Physiology 224(3): 514-518
Bíres, J. 1989: Interactive relations between copper, iron, zinc, arsenic, cadmium and lead in the liver in sheep after experimental poisoning with copper oxide Veterinarni Medicina 34(11): 665-674
Bostedt, H.; Jekel, E.; Schramel, P. 1990: The development of iron and copper concentrations in blood plasma of calves in the first days and weeks of life, equally a contribution to the larvaceous neonatal iron deficiency anemia Deutsche Tierärztliche Wochenschrift 97(10): 400-403
Kim, J.W.; Kim, J.H.; Shin, J.E.; Kil, D.Y. 2016: Relative bioavailability of copper in tribasic copper chloride to copper in copper sulfate for laying hens based on egg yolk and feather copper concentrations Poultry Science 95(7): 1591-1597
Imperato, F.; Perniola, G.; Mossa, B.; Marziani, R.; Perniola, F.; Stragapede, B.; Napolitano, C. 2002: The role of copper-releasing intrauterine device or levonorgestrel-releasing intrauterine system on uterine bleeding and iron status (prospective study of 8 years) Minerva Ginecologica 54(3): 271-278
Woolard, T.J. 1978: Copper toxicity Medical Journal of Australia 2(6): 270
Vinlove, M.P.; Britt, J.; Cornelius, J. 1992: Copper toxicity in a rabbit Laboratory Animal Science 42(6): 614-615
Johansson, I.; Ingelman-Sundberg, M. 1988: Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes Cancer Research 48(19): 5387-5390
Sternlieb, I. 1981: Clinical range of copper toxicity Medecine and Chirurgie Digestives 10(4): 327-330
Gürtler, H.; Schützler, H. 1971: Iron and copper balances in newborn calves Monatshefte für Veterinarmedizin 26(7): 255-261
1974: Simultaneous determination of copper and iron in serum Medizinische Monatsschrift 28(11): 508
Mousavi, S.; Abdollahi, M.; Ahmadi, A.; Najafi, A.; Pazouki, M.; Hadjibabaie, M.; Ziaee, S.; Hamishehkar, H.; Kebriaeezadeh, A.; Mojtahedzadeh, M. 2011: The dilemma of hyperoxia following positive pressure mechanical ventilation: role of iron and the benefit of iron chelation with deferasirox European Review for Medical and Pharmacological Sciences 15(10): 1141-1148
Venkateswerlu, G.; Sastry, K.S. 1979: Studies on copper toxicity in Neurospora crassa Indian Journal of Biochemistry and Biophysics 16(2): 84-87
Milne, D.B.; Omaye, S.T. 1980: Effect of vitamin C on copper and iron metabolism in the guinea pig International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 50(3): 301-308
Channa, M.L.; Burger, F.J.; Ubbink, J.B.; Reinach, S.G. 1994: Zinc, copper and iron balance in the vitamin B-6-deficient rat International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 64(3): 204-211
Lifshitz-Guinzberg, A.; García-Vigil, L.J.; Paniagua-Sierra, R.; Díaz-Benssussen, S.; Moreno-Aguilar, G. 1987: Plasma levels of iron, zinc and copper during antipyresis Gaceta Medica de Mexico 123(5-6): 105-111
Bernikova, E.M.; Molotkov, V.N. 1973: Iron and copper in the blood of patients with pulmonary tuberculosis Problemy Tuberkuleza 51(2): 48-50