Contribution of nitric oxide and sensory transmitters to non-adrenergic, non-cholinergic innervation of nasal blood vessels
Okita, W.; Ichimura, K.
Acta Oto-Laryngologica. Supplementum 539: 76-78
1998
ISSN/ISBN: 0365-5237 PMID: 10095867 Document Number: 489967
The possible contribution of a non-adrenergic, non-cholinergic (NANC) vasodilator mechanism in human nasal mucosa was studied using an in vitro muscle tension measuring technique. Strips of the nasal mucosa were suspended in a Magnus tube filled with Krebs solution and aerated with 95% O2. Isometric changes in tension were detected on administration of various drugs under electric stimulation and recorded with a transducer. The relaxing reaction under electrical train pulse stimulation with pretreatment of blockers of the autonomic nerves was suppressed by nitric oxide synthase inhibitor (L-NAME) and antagonists to the receptors of sensory nerve transmitters (Spantide, hCGRP8-37). This result suggests that nitric oxide, substance P and CGRP may be mediators in the NANC inhibitory nerve system.