Microsatellite instability of genome in cells of sporadic and hereditary carcinoma of the gastrointestinal tract
Vostriukhina, O.A.; Nikiforova, I.F.; Shtam, T.A.; Kantorov, S.L.; Tutaev, K.I.; Shumakov, A.R.; Komissarova, S.V.; Kalinovskiĭ, V.P.; Vasil'ev, S.V.; Kovalev, V.K.
Voprosy Onkologii 44(5): 509-514
1998
ISSN/ISBN: 0507-3758 PMID: 9884704 Document Number: 489647
Microsatellite instability (MIN) of human genome, i.e. instability of very short (1-5 nt) DNA tandem repeats, points to a deficiency in the mismatch repair system (MMR). To investigate the role of MMR in sporadic and hereditary carcinogenesis in the gastrointestinal tract, four types of carcinomas were compared: sporadic (GC), familial (FGC) gastric carcinoma, sporadic colorectal (CC) and hereditary nonpolyposis colorectal (HNPCC) carcinoma. No significant difference in MIN frequency was found between GC (9 out of 27) (33%) and CC (7 out of 29) (24%). In hereditary carcinoma group, MIN occurrence appeared 2-3 times as high: FGC in 7 out of 10 (70%) and HNPCC in 6 out of 8 patients (75%). No significant differences were recorded in MIN occurrence at early and later stages of the disease in all groups. Therefore, it can be suggested that disorders in the MMR develop at earlier stages of carcinogenesis and may be responsible for tumor progression.