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Late p53 mutation in head and neck oncogenesis

Mochón, A.; Esteban, F.; Ciges, M.; Luna, C.A.; Jiménez, M.C.

Anales Otorrinolaringologicos Ibero-Americanos 25(5): 433-446

1998

ISSN/ISBN: 0303-8874
PMID: 9807881
Document Number: 489407
p53 mutation are currently recognized as the commonest genetic event in human tumors. In this paper are studied, through immunochemistry, the p53 protein expression of 25 carriers from squamous cell carcinoma of the larynx and hypopharynx as well in the non tumoral mucosa of the larynx removed and corresponding metastases. Because of the great overexpression of this protein among tumors and its metastases, aside with the low expression in normal far-off mucous membranes of the studied growths, the AA. draw out the conclusion that p53 mutation is a late event by neck and head oncogenesis.

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