Apoptosis: the pharmacological aspects
Uteshev, D.B.; Sergeev, A.V.; Uteshev, B.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 61(4): 57-65
1998
ISSN/ISBN: 0869-2092 PMID: 9783113 Document Number: 488522
The article deals with the latest achievements in the interpretation of the mechanism of programmed cell death (apoptosis). The effect of drugs on the different stages of the apoptotic signal conduction is analysed. The earliest prospects of creating apoptosis regulating agents are planned. It is suggested that tests for apoptosis should be included in the list of obligatory ones in the preclinical studies of new biologically active compounds.