Clinical study on reduction of postpartum bleeding in cesarean section by misoprostol
Zhao, Y.; Li, X.; Peng, Y.
Zhonghua Fu Chan Ke Za Zhi 33(7): 403-405
1998
ISSN/ISBN: 0529-567X PMID: 10806698 Document Number: 487825
To observe the effects of misoprostol on reduction of postpartum bleeding in cesarcan section. One hundred and eighty-two cesarean sections were randomized into three groups: misoprostol group (n = 60), 600 micrograms misoprostol was given orally when peritoneum was incised; misoprostol and oxytocin group (n = 64), 600 micrograms misoprostol was given orally and 20 IU oxytocin was injected into uterine muscle immediately after delivery of baby. Oxytocin group (n = 58), 20 IU oxytocin was injected into uterine muscle and 20 IU intravenous injection immediately after delivery of baby. The amount of bleeding within 2 hours after delivery was measured. The mean amount of bleeding in misoprostol group was 212 +/- 56.0 ml, in misoprostol and oxytocin group was 208 +/- 55.4 ml, oxytocin group was 345 +/- 64.7 ml, respectively. The difference was significant P < 0.01 between misoprostol group and oxytocin group, there was no differences between misoprostol group and misoprostol plus oxytocin group. Misoprostol is more effective in reduction of postpartum bleeding than that of oxytocin.