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Hormone therapy of postoperative recurrent pancreatic carcinoma with octreotide and tamoxifen

Wenger, F.A.; Zieren, H.U.; Jacobi, C.A.; Müller, J.M.

Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 115: 1348-1350

1998

ISSN/ISBN: 0942-2854
PMID: 9931878
Document Number: 487618
In a prospective trial a combination of octreotide and tamoxifen was evaluated for its effect on tumour recurrence of R0-resected pancreatic carcinoma. Compared to the control group (n = 14), which was treated according to "best supportive care", the median survival times for the octreotide-tamoxifen group (n = 14) were 7 and 3.5 months respectively. In the octreotide-tamoxifen group patients suffered less from nausea, pain and fatigue (p < 0.05). Furthermore, there was a benefit of octreotide-tamoxifen therapy for global life quality.

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