The structural organization of the aortic endothelium in hypercholesterolemia and the effect of L-arginine
Tkachenko, M.M.; Stechenko, L.O.; Sahach, V.F.
Fiziolohichnyi Zhurnal 44(5-6): 59-64
1998
ISSN/ISBN: 2522-9028 PMID: 9866026 Document Number: 487404
Electron microscopic investigation of the rabbit thoracic aorta revealed endothelium to be most vulnerable to the damage in experimental hypercholesterolemia. Administration of precursor of nitric oxide L-arginine against the background of hypercholesterolemia resulted in activation of functional activity of the endothelium of aorta. This notion is supported by an increase of the quantity of protein-synthesizing structures (ribosomes, polysomes, canaliculi of endoplasmic network), secretory granules vs rabbits on atherogenic diet. At stimulation of NO-synthase activity of endothelium the dilatory reactions of aortal strips to acetylcholine are improved.