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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

Hart, M.J.; Jiang, X.; Kozasa, T.; Roscoe, W.; Singer, W.D.; Gilman, A.G.; Sternweis, P.C.; Bollag, G.

Science 280(5372): 2112-2114

1998

ISSN/ISBN: 0036-8075
PMID: 9641916
Document Number: 487172
Signaling pathways that link extracellular factors to activation of the monomeric guanosine triphosphatase (GTPase) Rho control cytoskeletal rearrangements and cell growth. Heterotrimeric guanine nucleotide-binding proteins (G proteins) participate in several of these pathways, although their mechanisms are unclear. The GTPase activities of two G protein a subunits, Ga12 and Ga13, are stimulated by the Rho guanine nucleotide exchange factor p115 RhoGEF. Activated Ga13 bound tightly to p115 RhoGEF and stimulated its capacity to catalyze nucleotide exchange on Rho. In contrast, activated Ga12 inhibited stimulation by Ga13. Thus, p115 RhoGEF can directly link heterotrimeric G protein a subunits to regulation of Rho. Copyright 1998 by the AAAS.

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