Significance of the heart-lung machine for the concept of minimal invasive heart surgery
Redling, F.; Prondzinsky, R.; Witthaut, R.; Fraunberger, P.; Werdan, K.; Zerkowski, H.R.
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 115: 1516-1519
1998
ISSN/ISBN: 0942-2854 PMID: 9931929 Document Number: 487015
Proinflammatory cytokines have been implicated in mediating myocardial dysfunction in a systemic inflammatory reaction following open heart surgery with extracorporeal circulation (ECC). The present study aimed to distinguish the surgical impact on cytokine release from the influence of ECC in a model of supported angioplasty. The extracorporeal circulation and not surgical trauma was found to be the main trigger of the systemic inflammatory response.