Cytogenetic analysis of hypophyseal adenoma. Study of 9 cases and review of the literature
Buonamici, L.; Roncaroli, F.; Frank, G.; Dal Cin, P.; Van den Berghe, H.; Calbucci, F.; Eusebi, V.
Pathologica 90(2): 116-119
1998
ISSN/ISBN: 0031-2983 PMID: 9619053 Document Number: 486295
To the best of our knowledge, no specific chromosomal abnormalities have been found in the literature in pituitary adenomas. In the present study, we investigated 9 cases of pituitary adenoma and reviewed the current literature. Nine cases of pituitary adenoma have been studied with immunohistochemistry and cytogenetic using short-term cultures. All tumors had a normal karyotype. Three cases were clinically non-secreting adenomas, three cases produced prolactin, two showed growth hormone production and one thyroid-stimulating hormone. One of the cases showed dural invasion. We compared our results with those published in the current literature. It appears that pituitary adenomas do not have specific numerical and structural abnormalities and mostly show a normal karyotype.