Factors related with compliance with tuberculosis chemoprophylaxis
Galvañ Olivares, F.; Santiuste de Pablos, C.
Medicina Clinica 111(17): 655-657
1998
ISSN/ISBN: 0025-7753 PMID: 9881347 Document Number: 485239
To determine therapeutic tolerance and compliance level with antituberculous chemoprophylaxis. 587 patients were proposed for antituberculous chemoprophylaxis with isoniazid from January 1995 to June 1996 in Murcia (Spain). 3.6% of the patients gave up treatment because of hepatic intolerance and 73% completed the prophylaxis. Non-compliance related factors were: social risk factors (odds ratio [OR] = 9.31), previous history of allergies (OR = 2.87), previous personal history of tuberculosis-related events (OR = 0.49) and interaction between sex and age. Support and intervention measures directed to risk groups of a social origin deem to be needed. Control measures and information provided to middle-aged males, with particular emphasis to the first weeks of prophylaxis, should also be implemented.