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Female fertility prognosis and diethylstilbestrol. Personal data and review of the literature

Laurent, S.; Lanoue, M.; Lecomte, C.; Bourgeois, L.; Lecomte, P.

Journal de Gynecologie Obstetrique et Biologie de la Reproduction 27(3): 277-284

1998

ISSN/ISBN: 0368-2315
PMID: 9648005
Document Number: 485186
Diethylstilbestrol (DES) exposure in utero in females is a cause of clear-cell adenocarcinoma of the cervix and of several anatomical and functional disorders of the genital tract. DES exposure must be evoked whenever counselling women for reproductive disorders. In France around 80,000 women have had in utero DES exposure. The cases of 4 young women who consulted our Reproduction Center for reproductive disorders illustrate the usual difficulties faced by these patients. In spite of their difficult past reproductive history (uterine malformations, repeated miscarriages, ectopic pregnancies) and low fertility rate, all four women conceived successfully, either after spontaneous or induced ovulation. We stress the need for adapted psychological and medical care which can lead to successful childbearing in the vast majority of these high-risk patients.

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