Radiation induced tumors
Gutiérrez Bayard, L.; Delgado López, L.; Tirado Bejarano, C.; Gómez Puerto, A.; García Fernández, J.L.
Anales de Medicina Interna 15(4): 219-223
1998
ISSN/ISBN: 0212-7199 PMID: 9608069 Document Number: 485139
Radiations at cellular level produce different effects, depending on type of radiation and irradiated tissue. The radiation-induced cancers are associated to non-letals genetics mutations, and to classify like radiation induced tumors is necessary that appear in the treatment volume, a long latency period (years), histolo-different to the primary lesion, enough doses quantitatively and that exists a greater incidence in the irradiated populations. The genetics mutations affect at tumoral suppressors gen(Gen RB I, p53, BRCA I, BRCA 2) and repressors gen (hMSH 2, hMLH I,...), they could be longer and multifocals mutations, and produce lack of cellular control and a greater predisposition to develop tumors and a probable risk of increment of radiosensitivity. We present some of the more representatives studies about radiation-induced tumors.