Effect of ethanol and polyethylene glycol-400 on frequency dependence of the inotropic effect of verapamil on the frog myocardium
Nesterov, V.P.; Korotkov, S.M.; Matveev, V.V.; Demina, I.N.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 84(1-2): 111-114
1998
ISSN/ISBN: 0869-8139 PMID: 9612865 Document Number: 484685
The PEG-400 was found to be neutral in respect to the frequency-dependent V negative inotropic action whereas ethanol enhanced this dependence. The findings suggest a possibility for V inotropic activity to be modified by lipophilic agents, provided they sterically complementary to hydrophobic domains of the Ca2(+)-channel structure.
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