Top Abstract Purchase Related
Home
>
Node
>
Subnode

Clinical trial of domestic drug polyoxidonium in secondary immunodeficiency

Borisova, A.M.; Laktionova, L.V.; Setdikova, N.Kh.

Terapevticheskii Arkhiv 70(10): 52-57

1998

ISSN/ISBN: 0040-3660
PMID: 9864806
Document Number: 484189
Aim. To test clinical efficiency and immunocorrectives characteristics of polyoxidonium in patients with chronic bronchitis (CB) and chronic recurrent furunculosis. Materials and methods. 56 patients entered the trial; 13 with CB in remission, 22 with CB in exacerbation and 21 with chronic recurrent furunculosis. Clinical examinations and tests were made before polyoxidonium therapy and 2-3 days after it. Immunological tests consisted of determination of subpopulation composition of peripheral blood lymphocytes, serum immunoglobulins and phagocytic activity of neutrophils. Results. Polyoxidonium is an effective and safe immunocorrector. It has a strong influence on functional activity of blood phagocytic cells. Conclusion. Polyoxidonium treatment of CB and chronic recurrent furunculosis results in positive shifts in hematological and immunological indices. This allows to recommend it for treatment of acute and chronic infections.

Document emailed within 1 workday
Secure & encrypted payments

Suntharasamai, P.; Martin, M.; Vanichseni, S.; van Griensven, F.; Mock, P.A.; Pitisuttithum, P.; Tappero, J.W.; Sangkum, U.; Kitayaporn, D.; Gurwith, M.; Choopanya, K.; Choopanya, K.; Vanichseni, S.; Prasittipol, B.; Srisuwanvilai, L-Ong.; Subhachaturas, W.; Sangkum, U.; Bussaratid, V.; Kaewkungwal, J.; Kitayaporn, D.; Migasena, S.; Phonrat, B.; Pitisuttithum, P.; Pungpak, S.; Suntharasamai, P.; Chaowanachan, T.; Cherdtrakulkiat, T.; Kittikraisak, W.; Leelawiwat, W.; Martin, M.; McNicholl, J.; Na-Pompet, S.; Sinthuwattanawibul, C.; Tappero, J.W.; van Grie 2009: Factors associated with incarceration and incident human immunodeficiency virus (HIV) infection among injection drug users participating in an HIV vaccine trial in Bangkok, Thailand, 1999-2003 Addiction 104(2): 235-242
Kalantzi, K.I.; Ntalas, I.V.; Chantzichristos, V.G.; Tsoumani, M.E.; Adamopoulos, D.; Asimakopoulos, C.; Bourdakis, A.; Darmanis, P.; Dimitriadou, A.; Gkiokas, S.; Ipeirotis, K.; Kitikidou, K.; Klonaris, I.; Kostaki, A.; Logothetis, D.; Mainas, K.; Mais, T.; Maragiannis, A.; Martiadou, K.; Mavronasos, K.; Michelongonas, I.; Mitropoulos, D.; Papadimitriou, G.; Papadopoulos, A.; Papaioakeim, M.; Sofillas, K.; Stabola, S.; Stefanakis, E.; Stergiou, D.; Thoma, M.; Zenetos, A.; Zisekas, S.; Goudevenos, J.A.; 2019: Comparison of Triflusal with Aspirin in the Secondary Prevention of Atherothrombotic Events; Α Randomised Clinical Trial Current Vascular Pharmacology 17(6): 635-643
Spinner, D.; Walter, J.; Vazquez-Gragg, M.; Bloise, T.; Stafford-Smith, M.; Faulkner, E.; Taekman, J. 2011: Php74 Clinical Trial Learning Curves Affect Outcomes Measurement, Patient Safety and Trial Success: Contributing Factors and a Potential Solution in Clinical Trial Simulation Value in Health 14(3): A24-A25
Afolabi, M.O.; Ndure, J.; Drammeh, A.; Darboe, F.; Mehedi, S.-R.; Rowland-Jones, S.L.; Borthwick, N.; Black, A.; Ambler, G.; John-Stewart, G.C.; Reilly, M.; Hanke, T.áš; Flanagan, K.L. 2013: A phase i randomized clinical trial of candidate human immunodeficiency virus type 1 vaccine MVA.HIVA administered to Gambian infants Plos one 8(10): E78289
Swanson, B.; Keithley, J.K.; Sha, B.E.; Fogg, L.; Nerad, J.; Novak, R.M.; Adeyemi, O.; Spear, G.T. 2011: Policosanol for managing human immunodeficiency virus-related dyslipidemia in a medically underserved population: a randomized, controlled clinical trial Alternative Therapies in Health and Medicine 17(2): 30-35
Salomon, H.E.; Pampuro, S.E.; Gu, Z.; Montaner, J.S.; Libonatti, O.; Wainberg, M.A. 1995: Basic and clinical aspects of drug resistance in human immunodeficiency virus type 1 infection Revista Argentina de Microbiologia 27(4): 214-229
Robiner, W.N.; Melroe, N.H.; Campbell, S.; Rhame, F.S.; Colón, E.; Chung, J.; Reaney, S. 1993: Psychological effects of participation and nonparticipation in a placebo-controlled zidovudine clinical trial with asymptomatic human immunodeficiency virus-infected individuals Journal of Acquired Immune Deficiency Syndromes 6(7): 795-808
Muga, R.; Tor, J.; Soriano, V.; Clotet, B.; Ribera, A.; Ginestá, C.; Melús, R.; Rey-Joly, C.; Foz, M.; Ribas-Mundó, M. 1988: Human immunodeficiency virus antigens and antibodies in parenteral drug addicts: correlations with a clinical study Medicina Clinica 91(8): 286-288
Sun, Y. 1984: Clinical phase Ii trial of a new antineoplastic drug, glyciphosphoramide (GPM) Zhonghua Zhong Liu Za Zhi 6(5): 375-378
Guy, W.; Cleary, P.; Switalski, R. 1977: A comparison of drug-trial schizophrenics with their clinical counterparts Psychopharmacology Bulletin 13(3): 44-45
Selby, G. 1970: A clinical trial of an antiserotonin drug, bc-105 in the prophylaxis of migraine Proceedings of the Australian Association of Neurologists 7: 37-43
Sun, Y. 1984: Clinical phase i trial of a new anti-neoplastic drug--glyciphosphoramide Zhonghua Zhong Liu Za Zhi 6(4): 293-295
Frimodt-Moller, C.; Hald, T.; Folkenborg, O. 1973: A controlled clinical trial of a new bladder spasmolytic drug--Urispadol Ugeskrift for Laeger 135(43): 2321-2324
Budhachandra, Y.; Ramesh, K.; Sumitra, G. 2007: Personality profile among Human Immunodeficiency Virus (HIV) positives and Acquired Immunodeficiency Syndrome (AIDS) patients of injecting drug users Kathmandu University Medical Journal 5(1): 38-41
Wallin, J.; Sjövall, J. 1981: Detection of adverse drug reactions in a clinical trial using two types of questioning Clinical Therapeutics 3(6): 450-452
Lallemant, M.; Jourdain, G.; Le Coeur, S.; Kim, S.; Koetsawang, S.; Comeau, A.M.; Phoolcharoen, W.; Essex, M.; McIntosh, K.; Vithayasai, V. 2000: A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators New England Journal of Medicine 343(14): 982-991
Katritsis, D.G.; Korovesis, S.; Karvouni, E.; Giazitzoglou, E.; Theodorou, S.; Kourlaba, G.; Panagiotakos, D.; Voridis, E. 2006: Direct versus predilatation drug-eluting stenting: a randomized clinical trial Journal of Invasive Cardiology 18(10): 475-479
Abate, G.; Cuccurullo, F.; Curti, A. 1973: Clinical trial of a new anti-anginal drug: 2-benzofuryl-p-chlorophenyl carbinol (clobenfurol) Minerva Cardioangiologica 21(2): 145-153
Van der Merwe, A.M.; Falkson, G.; Sandison, A.G.; van Dyk, J.J.; Falkson, H.C. 1973: Advanced lung cancer: a clinical trial of radiotherapy plus two drug combination regimens South African Medical Journal 47(46): 2219-2222
Mehrotra, T.N.; Aneja, G.K.; Arora, V.; Goel, S.; Singh, V.S. 1990: Valproate sodium in epilepsy. a clinical trial including monitoring of drug levels Journal of the Association of Physicians of India 38(4): 277-279