Changes of early renal function before and after using mannitol in patients with cerebral apoplexy
Zhu, X.; Luo, J.A.; Liu, Z.; Xiao, P.; Liao, K.; Hu, Z.
Hunan Yi Ke Da Xue Xue Bao 22(2): 159-161
1997
ISSN/ISBN: 1000-5625 PMID: 9868062 Document Number: 483499
The alteration of renal function after initiation of mannitol infusion were monitored in 20 patients with cerebrovascular accident to evaluate whether mannitol has nephrotoxicity effects. Serum creatinine and urea nitrogen were increased after initiation of mannitol infusion, but hadn't reached statistical significance. Urinary and serum alpha-1-microglobulin, beta-2-microglobulin and urinary NAG, gamma-GT were significantly increased after 5 apprx 10 days successive infusion of mannitol (P lt 0.05). The results suggest that the acute nephrotoxicity effect of mannitol should not be ignored.