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The role of potential duplication of time for the neoplastic cells in patients with head and neck cancer treated by radiation

Rogowski, W.

Otolaryngologia Polska 51(6): 531-536

1997

ISSN/ISBN: 0030-6657
PMID: 9640048
Document Number: 483308
Proliferation potential of tumour cells is one of the most important features of malignant neoplasms. This factor can be assessed by measurement of the potential doubling time (Tpot). This method includes the single intravenous injection of thymidine analogue (iodo- or bromodeoxyuridine) with subsequent single biopsy of the tumour and simple calculation using flow cytometry data of the specimen. The preliminary results of clinical trials show that Tpot determined prior to treatment can serve as an independent prognostic factor in patients with head and neck cancer receiving conventional radiotherapy. This assay may also help to selected a subgroup of patients with high proliferation capacity for whom application of accelerated radiotherapy regimens may be advantageous. The aim of this paper is to describe the methodology of Tpot measurement and to review the clinical radiotherapy trials involving Tpot measurement.

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