Administration of bisphosphonate prevents disuse bone atrophy induced by tail suspension
Kurokouchi, K.; Ito, T.; Ohmori, S.; Kanda, K.; Murata, Y.; Yasukawa, K.; Izumi, R.; Inazu, M.; Iwata, H.; Seo, H.
Environmental Medicine Annual Report of the Research Institute of Environmental Medicine Nagoya University 41(1): 16-17
1997
ISSN/ISBN: 0287-0517 PMID: 12523373 Document Number: 482764
We recently demonstrated that osteopenia induced by rat tail-suspension was associated with an initial increase in bone resorption. To study the significance of the increase in early bone resorption for osteopenia, we investigated whether administration of YH529, a third-generation bisphosphonate, prevents the development of osteopenia as evidenced by increased wet weight of the femur, together with its calcium and phosphorus contents, when compared with those of tail-suspended rats treated with the vehicle alone. These results suggested that the initial increase in bone resorption plays an important role in the development of osteopenia induced by tail suspension.