Molecular-biologic aspects of interaction between nervous and immune systems
Korneva, E.A.; Golovko, O.I.; Kazakova, T.V.
Voprosy Meditsinskoi Khimii 43(5): 321-329
1997
ISSN/ISBN: 0042-8809 PMID: 9446322 Document Number: 482315
The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulating interleukin-2 (IL-2) gene expression was discussed. The physico-chemical and functional parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied. The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown. The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.