Clinical and evolutive study of plasma cell leukemia. Apropos of 9 cases
Panizo Santos, C.; Cuesta Palomero, B.; Calasanz Abinzano, M.J.; Rifón Roca, J.; Rocha Hernando, E.
Revista Clinica Espanola 197(5): 341-345
1997
ISSN/ISBN: 0014-2565 PMID: 9280968 Document Number: 482152
Nine patients were diagnosed with plasma cell leukemia (PCL) from 1982-1995 at our hospital. Seven patients had primary PCL and the other two patients a secondary from. In this study the clinical and analytical features are reported, as well as the therapy and response obtained in these patients. Also, the karyotype findings in bone marrow of four of these patients are reported. At diagnosis, the most common symptom was bone pain which was associated with osteolytic lesions or diffuse bone demineralization. Analytical features were similar to those reported in other series of patients with PCL. Different therapeutical regimens were used, and VAD was the most commonly employed. Two patients underwent consolidation therapy with autologous transplantation of hemopoietic stem cells. The mean survival time was 5.5 months. Although PCL prognosis associated with chemotherapy is still poor, myeloablative therapy with hemopoietic support can increase the survival length in these patients.