Chronochemotherapy for cancer
Akazawa, S.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 24(10): 1191-1202
1997
ISSN/ISBN: 0385-0684 PMID: 9279336 Document Number: 481729
The chronomodulation of anticancer drugs arouses our interest as a method for cancer chemotherapy. The author reviewed recent clinical studies regarding circadian rhythms in 1) target tissues: healthy and cancer tissues; 2) chronopharmacology of anticancer drugs; and 3) chronotoxicity of anticancer drugs. A brief review is made of the main results of clinical phase II trials.
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