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Cerebellar granule cell membranes and glutamate mediates transactivation of glutamine synthetase promoter

Kedar, V.; Purohit, H.; Freeze, E.; Hempel, F.

Indian Journal of Experimental Biology 35(2): 123-127

1997

ISSN/ISBN: 0019-5189
PMID: 9315219
Document Number: 481268
Potential region of glutamine synthetase promoter driving astrocyte-specific transactivation, mediated by cerebellar granule cell membrane and glutamate has been identified by deletion analysis of promoter and transient transfection. The promoter region from -420 to -765 was found to be potentially important for this transactivation. These results provided further evidence for importance of neuronal-glial and glutamate-glial interactions in regulation of glial gene expression.

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