Renal pathology of VTEC related HUS
Shigematsu, H.
Nihon Rinsho. Japanese Journal of Clinical Medicine 55(3): 721-725
1997
ISSN/ISBN: 0047-1852 PMID: 9086787 Document Number: 480791
Renal histopathology of verotoxin producing escherichia coli(VTEC) related hemolytic uremic syndrome (HUS) was described. Endothelial damage is expressed in renal small arteries and glomeruli as luminal narrowing due to endothelial swelling and subendothelial edema. Extracellular matrix shows reticularization and/or mesangiolysis in glomeruli. Although HUS and thrombotic thromocytopenic purpura (TTP) is recently considered as a single entity, the tissue expression is different. In the latter endothelial proliferation is profound resulting in arteriolar deteriolation such as glomeruloid structure.