An integrated model of sleep regulation
Ruggiero, C.; Giacomini, M.; Schiavi, G.; Nobili, L.; Ferrillo, F.
Studies in Health Technology and Informatics 43 Pt B: 581-585
1997
ISSN/ISBN: 0926-9630 PMID: 10179732 Document Number: 480232
We present a new model of sleep regulation which integrates the two process model and the limit cycle reciprocal interaction model. In the two process model the interaction of a homeostatic process (S signal) and of a circadian process determines the timing of sleep and waking. In the limit cycle model, the NREM-REM sleep cycle is generated by the reciprocal interaction of two coupled cell population. The present model integrates the two considered models introducing the trigger REM-NREM generated by the REM-ON signal and activated when REM-ON overcomes the S signal.