Experimental model of chronic bronchitis
Kwaśniewski, A.; Krasnowska, M.; Rabczyński, J.; Kuryszko, J.J.
Pneumonologia i Alergologia Polska 65(1-2): 27-34
1997
ISSN/ISBN: 0867-7077 PMID: 9289299 Document Number: 480199
In 20 rats bronchitis was evoked by permanent 12-week long inhalation of SO2. For this purpose a special chamber with gas supply was prepared. In all rats exposed to SO2 changes in cellularity of BALF were found (a statistically significant increase of the percent of macrophages and neutrophils). Histologic examination revealed bronchial changes especially in epithelium. The method applied, based on an original technology is cheap and effective and can be recommended in developing experimental bronchitis.
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