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Two cases of hypergranular acute lymphoblastic leukemia

Bolado-Martínez, E.; Vivanco-Jiménez, M.; García-Ramírez, F.; Ruiz-Reyes, G.; Ruiz-Argüelles, A.; Ruiz-Argüelles, G.J.

Revista de Investigacion Clinica; Organo del Hospital de Enfermedades de la Nutricion 49(3): 227-230

1997

ISSN/ISBN: 0034-8376
PMID: 9294964
Document Number: 480093
Two patients with hypergranular acute lymphoblastic leukemia are presented: they represent 1.4% of patients with acute lymphoblastic leukemia studied and treated in a single institution in the past 12 years. This frequency is substantially lower than that reported in Caucasian populations. The blast cells of the patients disclosed an early-B phenotype, displaying CD45, CD10 and CD19 antigens. The cytoplasmic granules were positive for the PAS reaction. Both patients died early after starting treatment; a poor prognosis has been recorded previously for patients with this type of malignancy.

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