Evaluation of treatment with cyclosporine in three patients with pulmonary fibrosis
Undurraga, A.; Meneses, M.; Oyarzún, M.
Revista Medica de Chile 125(6): 690-695
1997
ISSN/ISBN: 0034-9887 PMID: 9515289 Document Number: 479679
There are few reports on the use of cyclosporine in idiopathic pulmonary fibrosis, in experimental animals or humans. We report three patients with advanced pulmonary fibrosis in whom steroid therapy failed and that received cyclosporine in a dose of 3 to 5 mg/kg for three to five months. One patient developed systemic hypertension that subsided reducing the dose of cyclosporine. No positive changes in dyspnea were obtained and pulmonary function tests deteriorated during the treatment period. We conclude that cyclosporine treatment had no clinical benefit in these patients with pulmonary fibrosis.