Fertility control with long-acting injectable steroids. A preliminary report
Zañartu, J.; Rice-Wray, E.; Goldzieher, J.W.
Obstetrics and Gynecology 28(4): 513-515
1966
ISSN/ISBN: 0029-7844 PMID: 5925038 Document Number: 479557
Medroxyprogesterone acetate in single intramuscular injections ranging from 200 to 1,000 mg, with and without supplemental estrogen, was tested in 310 women as a means of fertility control. During 1638 woman-months of use no pregnancies occurred until 10-11 mo after a single injection. The menstrual rhythm was entirely disorganized but a brief supplemental course of oral estrogen reinstituted cyclic withdrawal bleeding. Other side effects were insignificant. There was no interference with lactation.