Chirality and drugs
Husson, H.P.
Annales Pharmaceutiques Francaises 55(1): 1-4
1997
ISSN/ISBN: 0003-4509 PMID: 9138315 Document Number: 479157
Following a brief historical review of the notion of chirality, the importance of the relationship between pharmacological activity and the enantiomeric forms of drugs is indicated. Different approaches for the preparation of optically-pure molecules are discussed, and an original strategy, known as the "CN(R,S) method", is described. To conclude, an application of this method in the synthesis of a pharmacologically-active molecule is presented.