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Somatic cell mutations in cancer epidemiology

Albertini, R.J.; Hayes, R.B.

Iarc Scientific Publications 142: 159-184

1997

ISSN/ISBN: 0300-5038
PMID: 9354918
Document Number: 478659
Somatic cell mutations arising in vivo in reporter genes and in cancer-associated genes may now be measured in humans. Background mutation levels and mutational responses following various mutagen exposures are reviewed in this chapter. The detection methods are compared for similarities and differences based on the underlying biology of the systems. Currently available data on molecular mutational spectra are reviewed and the utility of such information is discussed in terms of mutagen exposure characterization and for defining the mutagenic basis of carcinogenesis. In addition to the reporter gene assays, recently developed assays for mutation in cancer-associated genes are considered. The strengths and limitations of using somatic cell mutations for cancer epidemiology and areas for future research are discussed.

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Solov'ev, V.V.; Rogozin, I.V.; Kolchanov, N.A. 1989: Somatic hypermutagenesis in immunoglobulin genes. I. Connection of somatic mutations with repeats. a statistical weighting method Molekuliarnaia Biologiia 23(3): 783-794
Bignell, G.R.; Barfoot, R.; Seal, S.; Collins, N.; Warren, W.; Stratton, M.R. 1998: Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer Cancer Research 58(7): 1384-1386
Gong, K.; Zhang, Z.; Xin, D. 2001: Frequent somatic mutations of the von Hippel-Lindau tumor suppressor gene in primary sporadic human renal clear cell carcinomas Zhonghua Yi Xue Za Zhi 81(3): 142-144
Khalizev, A.E.; Pyzhov, A.P.; Shapiro, N.I. 1976: Development of spontaneous mutations in somatic mamalian cells and DNA replication. II. Expression of gene mutations in cultured cells Genetika 12(11): 51-60
Hemminki, K.; Thilly, W.G. 2004: Implications of results of molecular epidemiology on DNA adducts, their repair and mutations for mechanisms of human cancer Iarc Scientific Publications 157: 217-235
Burnouf, D.; Miturski, R.; Nagao, M.; Nakagama, H.; Nothisen, M.; Wagner, J.; Fuchs, R.P. 2000: Molecular approach in cancer epidemiology: early detection of carcinogen-induced mutations in a whole genome (Review) International Journal of Molecular Medicine 5(1): 15-20
Mitsudomi, T.; Oyama, T.; Gazdar, A.F.; Minna, J.D.; Okabayashi, K.; Shirakusa, T. 1992: Mutations of ras and p53 genes in human non-small cell lung cancer cell lines and their clinical significance Nihon Geka Gakkai Zasshi 93(9): 944-947
Zhang, R.; Li, Y.; Chen, Y.; Liu, X.; Wang, Z.; Sun, H.; Zheng, Y.; Ding, Z.; Lan, L.; Li, M.; Qin, J.; Chen, X. 2015: Clinical implications of the concentration and EGFR/KRAS mutations of plasma cell free DNA of patients with lung cancer and esophageal cancer Zhonghua Yi Xue Za Zhi 95(47): 3839-3842
Dong, Q.-g.; Han, B.-h.; Huang, J.-s.; Yang, L.-m.; Huang, J.; Zhao, C.-y.; Lu, L.-q. 2006: Analysis of EGFR mutations in 176 cases of non-small cell lung cancer Zhonghua Zhong Liu Za Zhi 28(9): 686-690
Petmitr, S.; Makthiengtrong, S.; Sutinont, P.; Migasena, P. 1999: p53 gene mutations in non-small cell lung cancer from Thai patients Journal of the Medical Association of Thailand 82(3): 250-255
Albertini, R.J.; Nicklas, J.A.; O'Neill, J.P. 1986: Molecular characterization of somatic gene mutations arising in vivo in humans Progress in Clinical and Biological Research 207: 77-85
Lozyns'ka, M.R.; Hnateĭko, O.Z.; Havryliuk, I.I. 1994: The level of spontaneous genomic mutations in the somatic cells of human embryos Tsitologiia i Genetika 28(3): 70-74
Lehman, T.A.; Bennett, W.P.; Metcalf, R.A.; Welsh, J.A.; Ecker, J.; Modali, R.V.; Ullrich, S.; Romano, J.W.; Appella, E.; Testa, J.R. 1991: P53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines Cancer Research 51(15): 4090-4096
Carney, D.N.; Edgell, C.J.; Gazdar, A.F.; Minna, J.D. 1979: Suppression of malignancy in human lung cancer (A549/8) times mouse fibroblast (3T3-4E) somatic cell hybrids Journal of the National Cancer Institute 62(2): 411-415
Sharon, J.; Gefter, M.L.; Wysocki, L.J.; Margolies, M.N. 1989: Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten Journal of Immunology 142(2): 596-601
Zhuang, Z.; Vortmeyer, A.O.; Pack, S.; Huang, S.; Pham, T.A.; Wang, C.; Park, W.S.; Agarwal, S.K.; Debelenko, L.V.; Kester, M.; Guru, S.C.; Manickam, P.; Olufemi, S.E.; Yu, F.; Heppner, C.; Crabtree, J.S.; Skarulis, M.C.; Venzon, D.J.; Emmert-Buck, M.R.; Spiegel, A.M.; Chandrasekharappa, S.C.; Collins, F.S.; Burns, A.L.; Marx, S.J.; Lubensky, I.A. 1997: Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas Cancer Research 57(21): 4682-4686
Kovalchuk, O.; Chyczewska, E.; Niklinska, W.; Niklinski, J.; Naumnik, W.; Chyczewski, L. 2001: K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer Folia Histochemica et Cytobiologica 39(Suppl 2): 68-69
Morodomi, Y.; Okamoto, T.; Kohno, M.; Katsura, M.; Takada, K.; Suzuki, Y.; Fujishita, T.; Kitahara, H.; Shimamatsu, S.; Yoshida, T.; Tagawa, T.; Okano, S.; Maehara, Y. 2015: Associations between driver gene mutations and cytotoxic chemosensitivity in patients with non-small cell lung cancer Anticancer Research 35(3): 1791-1796
Dahse, R.; Berndt, A.; Kosmehl, H. 2008: PCR-based testing for therapy-related EGFR mutations in patients with non-small cell lung cancer Anticancer Research 28(4b): 2265-2270
Vorechovský, I.; Undén, A.B.; Sandstedt, B.; Toftgård, R.; Ståhle-Bäckdahl, M. 1997: Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis Cancer Research 57(21): 4677-4681