Do effector and memory T helper cells also need B7 ligand costimulatory signals?
Gause, W.C.; Mitro, V.; Via, C.; Linsley, P.; Urban, J.F.; Greenwald, R.J.
Journal of Immunology 159(3): 1055-1058
1997
ISSN/ISBN: 0022-1767 PMID: 9233595 Document Number: 477965
Blocking B7 ligand-costimulatory molecules can inhibit a primary T-dependent immune response, but whether these interactions also mediate ongoing or memory immune responses is less clear. Development of immunotherapies based on blocking B7 ligand interactions would be limited if they were effective only at the initiation of an immune response. We discuss the conditions under which T helper effector and memory cells may or may not require B7 ligand interactions for their function.