Primary sclerosing cholangitis with itching treated during pregnancy with ursodeoxycholic acid
Christensen, K.L.; Andersen, B.N.; Vilstrup, H.
Ugeskrift for Laeger 159(48): 7151-7153
1997
ISSN/ISBN: 0041-5782 PMID: 9417723 Document Number: 477834
A 23-year old woman with primary sclerosing cholangitis was being treated with ursodeoxycholic acid (URSO). When pregnancy was diagnosed, she was already through the first trimester. The treatment was discontinued, but her symptoms including severe pruritus recurred immediately, and the biochemical markers of bile duct obstruction worsened. It was necessary to start URSO-treatment again, which relieved her symptoms and improved the biochemistry. The remaining part of the pregnancy was uncomplicated, there were no malformations and so far, the baby is doing fine. URSO may be a possible treatment for severe intrahepatic cholestasis and pruritus during pregnancy.