A case of Wilson-Mikity syndrome with marked and monoclonal elevation of IgM in blood
Kurata, C.; Morita, K.; Takaoka, N.; Kubota, C.; Takahashi, Y.; Yoshida, Y.; Yoshioka, A.; Okamoto, Y.; Nakano, H.
Rinsho Byori. Japanese Journal of Clinical Pathology 45(3): 282-285
1997
ISSN/ISBN: 0047-1860 PMID: 9086837 Document Number: 476216
Wilson-Mikity syndrome, a chronic respiratory insufficiency occurring in premature newborn infants, is known to show an elevation of serum IgM, but its etiology is obscure. We studied the immunological properties of IgM in a female infant of this syndrome, whose IgM in cord blood was very high level at 639.1 mg/dl with monoclonal elevation. The IgM bound to protein(s) in human umbilical venous endothelial cells and in human lung tissue. However, IgMs from this patient after recovery, from patient's mother and from another normal newborn did not bind to the proteins. Tissue-binding activity of the patient's IgM may be associated with tissue damages in this syndrome.