The photogenotoxicity of titanium dioxide particles
Nakagawa, Y.; Wakuri, S.; Sakamoto, K.; Tanaka, N.
Mutation Research 394(1-3): 125-132
1997
ISSN/ISBN: 0027-5107 PMID: 9434851 Document Number: 475969
We employed a series of in vitro genotoxicity assays--a single cell gel (SCG) assay with mouse lymphoma L5178Y cells, a microbial mutation assay with Salmonella typhimurium, a mammalian cell mutation assay with L5178Y cells, and a chromosomal aberration assay with Chinese hamster CHL/IU cells--to evaluate the photogenotoxicity of titanium dioxide (TiO2) particles. Without UV/visible light irradiation, TiO2 particles exhibited no or weak genotoxicity. With irradiation, however, TiO2 particles exhibited significant genotoxicity in the SCG and chromosomal aberration assays. Therefore, we concluded that TiO2 particles are photogenotoxic.