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Promotion of the formation of phenylalanine-thymine cross-linked products by free radicals formed during carbon tetrachloride activation with benzoyl peroxide in model systems. a mass spectrometric structural study

Castro, G.D.; Castro, J.A.

Research Communications in Molecular Pathology and Pharmacology 98(1): 85-90

1997

ISSN/ISBN: 1078-0297
PMID: 9434318
Document Number: 475941
Reaction mixtures containing phenylalanine methyl ester and thymine in pure carbon tetrachloride in the presence of benzoyl peroxide produced trichloromethyl and trichloromethylperoxyl free radicals which via hydrogen abstraction reactions sparked the formation of phenylalanine-thymine adducts, whose structures were elucidated by mass spectrometry. If similar type of reaction occurred under biological conditions, significant deleterious consequences might be anticipated.

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