P53 protein expression in malignant germ cell tumor of ovary and its relationship with clinical course and prognosis
Gao, G.; Peng, Z.; Wang, H.; Chen, A.; Yao, X.
Hua Xi Yi Ke da Xue Xue Bao 28(4): 420-423
1997
ISSN/ISBN: 0257-7712 PMID: 10683959 Document Number: 475860
To study the relationship of P53 protein expression with clinical course and prognosis in malignant germ cell tumor of ovary P53 protein expression was examined by immunohistochemical ABC methods in 82 cases of the neoplasm and 20 cases of normal ovary tissue. The results showed that no expression of P53 protein was detected in normal ovarian tissue. The total expression rate of P53 protein was 24.39% in neoplasm, and the expression was not significantly correlated with the different histological types of neoplasm. The study however found that the protein expression of p53 gene was significantly correlated with the clinical stages and prognosis of the neoplasm.