Role of nitric oxide in pathogenesis of pregnancy induced hypertension
Liu, Y.; Song, Y.; Jiang, H.
Zhonghua Fu Chan Ke Za Zhi 32(12): 738-741
1997
ISSN/ISBN: 0529-567X PMID: 9772439 Document Number: 475821
To investigate the role of nitric oxide (NO) in pathogenesis of pregnancy induced hypertension (PIH). N(G)-nitro-L-arginine-methyl-ester (L-NAME) was used to inhibite the synthesizing of NO in the third trimester of pregnancy rats. Indices including HGB, PLT, HCT, protein uria, serum endothelin (ET), thromboxane B2(TXB2), 6-keto-PGF1 alpha and blood pressure in pregnant rats were measured. The length, weight of body, liver and brain of full-term newborn rats and the weight and pathological changes of placenta were observed. After inhibition of NO synthesis, blood pressure were consistently high. The protein uria, HCT, ET, TXB2/6-keto-PGF1 alpha were significantly higher and PLT was significantly lower than that of control group. The length, weight of body and placenta in neonatal rats were lower than those of the control group (P < 0.01). Severe ischimic lesion, thrombosis of vessels and endothelial proliferation in placenta were observed. NO plays an important role in pathogenesis of PIH.